An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques (HTML)
Singer,Rachel; Mawson,Paul; Derby,Nina R.; Rodriguez,Aixa; Kizima,Larisa; Menon,Radhika; Goldman,Daniel; Kenney,Jessica; Aravantinou,Meropi; Seidor,Samantha; Gettie,Agegnehu; Blanchard,James; Piatak Jr.,Michael; Lifson,Jeffrey D.; Fernandez-Romero,Jose A.; Robbiani,Melissa; Zydowsky,Thomas M.
Science Translational Medicine 4(150):
Publication date: 2012
Microbicides may prevent HIV and sexually transmitted infections (STIs) in women; however, determining the optimal means of delivery of active pharmaceutical ingredients remains a major challenge. We previously demonstrated that a vaginal gel containing the non-nucleoside reverse transcriptase inhibitor MIV-150 partially protected macaques from SHIV-RT (simian/HIV reverse transcriptase) infection, and the addition of zinc acetate rendered the gel significantly protective. We test the activity of MIV-150 without the addition of zinc acetate when delivered from either ethylene vinyl acetate (EVA) or silicone intravaginal rings (IVRs). MIV-150 was successfully delivered, because it was detected in vaginal fluids and tissues by radioimmunoassay in pharmacokinetic studies. Moreover, EVA IVRs significantly protected macaques from SHIV-RT infection. Our results demonstrate that MIV-150-containing IVRs have the potential to prevent HIV infection and highlight the possible use of IVRs for delivering drugs that block HIV and other STIs.