More than 170 million women around the world use contraceptives developed by the Center for Biomedical Research (CBR) or based on our technologies.

Still, 200 million women worldwide have an unmet need for a modern method of contraception; 1.5 million people are newly infected with HIV every year; and more than 1 million people acquire a sexually transmitted infection every day.

A range of product options is essential to tackle the ongoing burdens of unintended pregnancy, HIV, and sexually transmitted infections. CBR’s innovations offer individuals with options that meet their needs and protect sexual and reproductive health at various points in their lives. Most recently, the Council has secured regulatory approvals of Annovera®, the one-year contraceptive vaginal ring, and DapiRing™, the one-month vaginal ring that can reduce the risk of HIV acquisition.

CBR researchers develop the next generation of safe, effective contraception and HIV and STI prevention options. Products in development include:

Next-generation female contraceptive products

New contraceptive methods can help millions of women with an unmet need for contraception and millions more who may be dissatisfied with current methods.

  • A 3-month Nestorone®/estradiol intravaginal ring to prevent unintended pregnancy is in clinical development. This ring is designed to have fewer side effects compared to ethinyl estradiol products currently on the market.
  • A Nestorone®-only vaginal ring for contraception in those who have estrogen sensitivities, those who are at higher risk of venous thromboembolism (VTE), and postpartum breastfeeding women.

New approach to male contraception

CBR addresses the lack of reversible contraceptive options for men.

  • A transdermal Nestorone®/Testosterone gel applied daily to the shoulders is currently in clinical trial. The gel would be a novel, easy-to-use, reversible contraceptive method and would be the first-of-its-kind contraceptive option for men.

Innovative multi-purpose prevention technologies

CBR researchers lead the development of a new generation of multi-purpose prevention technologies (MPTs) that protect against HIV, other STIs, and/or unintended pregnancy.

Additional indications

Council researchers have decades of experience working with active pharmaceutical ingredients for contraception and HIV and STI prevention. Through this work, our researchers explore other health uses for these active pharmaceutical ingredients.

  • A Nestorone® formulation to treat multiple sclerosis (MS), reduce symptoms, and delay disease progression. It would be an adjuvant therapy in addition to existing MS disease-modifying agents (all of which address immune function) that patients currently receive. Experimental animal models confirm that Nestorone® triggers myelin regeneration which could, if successful in humans, further reduce episodes of relapse and prevent permanent disability.
  • A self-administered, topically active intranasal product containing QGriffithsin and carrageenan that would be used to prevent infection with SARS-CoV-2 and potentially other emerging coronaviruses.